Sc CO2 Decellularization
Regenerative medicine and tissue engineering
Challenge
The market for decellularization in regenerative medicine continues to grow, offering promising solutions for repairing and regenerating various tissues and organs.
Inadequate Decellularization Methods for Tissue Engineering
- Traditional decellularization methods often result in the loss of crucial extracellular matrix components.
- Current techniques may not effectively remove cellular debris and antigens, limiting the potential of decellularized tissues.
Sc CO2 solution
We develop an innovative decellularization process using Sc CO2
- No waste, no residue, no solvent, non toxic
- Preserves mechanical and biological properties
- Effectively decellularizes xenograft and allograft materials.
- Maintains native structure for enhanced healing and recellularization.
- Achieves complete cellular material removal while preserving vital extracellular matrix components
- Provides highly clean and mechanically superior biomaterials
- Reduced process duration
- Meet the requirements of tissue engineering applications
Market applications
Regenerative medicine and tissue engineering
- Organ and tissue regeneration
- Wound healing and skin grafts
Services
- Contract Research Service: Feasibility, optimization, scale-up
- Patent licensing and co-development
- Production
To further expand our impact, we are actively seeking partnerships for collaborative development initiatives.
Join us in exploring co-developing innovative solutions that drive progress in the industry.
Production
Providing a Global Alternative Solution
After conducting successful feasibility and scale-up studies, we offers the following services:
- Scalable Modular Unit Design: we assist in dimensioning scalable modular units tailored to your specific needs
- Implementation of Units: We support the implementation of units based on the outcomes of our studies.
- Financial Intervention and Co-Financing: we can provide financial support or co-finance projects, offering different legal structures such as dedicated subsidiaries.
- Pilot Testing and Production: Leveraging ScCO2 technology, we specialize in extraction, particle generation, encapsulation of compounds and sterilization processes.
Competitive advantages
CO2 above a certain temperature and pressure (*)
offers the advantages of both a gas and a liquid:
CLEAN
- Zero waste, no residue, no solvent. Nontoxic
ADDED VALUE
- Low T° (32°C): heat-sensitive products
- (currently solvent often T° > 60°C)
- Minimizes risk of thermal/chemical degradation
- Penetrating power (density of a liquid, diffusivity of a gas)
- Better unimodal size/population distribution
- Obtain precise control over encapsulation
- Avoids formation of unwanted by-products
- Better control of product properties (encapsulation)
- Biocidal properties of CO2 (sterilization)
- More homogeneous and optimal properties (APIs)
- Enhancing product stability and bioavailability
- Particle size >60 nm (vs microfluidique > 5000 nm)
COMPETITIVE and EFFICIENT
- Faster and compact process (no need separation steps)
- Reduced process time (5 to 10 times)
- Reduced operation cost (from to 2 to 4 times)
- Compact, modular and integrated process
(*) Tc=31°C, PC=73,8 bar
