Micronisation
Sustained release delivery system
Challenge
Advantages of micronization:
- Enhanced solubility and bioavailability: micronization increases the surface area of particles, resulting in improved dissolution rates and enhanced solubility of substances.
- Improved stability and extended shelf life: by reducing particle size through micronization, the overall stability of the formulation can be increased. This is particularly beneficial for creams and spreads that need to maintain their quality and efficacy over an extended period.
- Enhanced texture and sensory experience: the smaller particle size allows for better dispersion and distribution, resulting in a more pleasant sensory experience for users.
- Increased efficacy and targeted delivery: The increased surface area achieved through micronization facilitates better interaction between the active ingredients and the target site of action
Sc CO2 solution
Advantages of carbon dioxide micronization:
- Cost-effective supercritical process.
- Requires minimal amounts of carbon dioxide
- Process volume can be confined to a static mixer
- Achieves efficient micronization of compounds
- No waste, no residue, no solvent, non toxic
- Enhancing product stability and bioavailability
Market applications
Cosmetics, Nutraceuticals, Food, Pharma, Chemical, Agriculture
- Pharmaceuticals: Improved drug solubility, bioavailability, and controlled release
- Food and beverage: Enhanced flavors, powdered ingredients, and texture improvement
- Cosmetics: Refined pigments, color dispersion, and improved texture
- Chemical industry: Fine powders, improved reactivity, and dispersibility
- Nanotechnology: Precursor for nanoparticle production with controlled properties
- Agriculture: Enhanced effectiveness and dispersion of pesticides and fertilizers
Competitive advantages
CO2 above a certain temperature and pressure (*)
offers the advantages of both a gas and a liquid:
CLEAN
- Zero waste, no residue, no solvent. Nontoxic
ADDED VALUE
- Low T° (32°C): heat-sensitive products
- (currently solvent often T° > 60°C)
- Minimizes risk of thermal/chemical degradation
- Penetrating power (density of a liquid, diffusivity of a gas)
- Better unimodal size/population distribution
- Obtain precise control over encapsulation
- Avoids formation of unwanted by-products
- Better control of product properties (encapsulation)
- Biocidal properties of CO2 (sterilization)
- More homogeneous and optimal properties (APIs)
- Enhancing product stability and bioavailability
- Particle size >60 nm (vs microfluidique > 5000 nm)
COMPETITIVE and EFFICIENT
- Faster and compact process (no need separation steps)
- > Reduced process time (5 to 10 times)
- Reduced operation cost (from to 2 to 4 times)
- Compact, modular and integrated process
(*) Tc=31°C, PC=73,8 bar
How does it work ?
The Sc CO2 micronization process offers several advantages, including the ability to produce fine particles with controlled size distributions, minimal risk of contamination, and preservation of the material's integrity. It is widely used in industries such as pharmaceuticals, food processing, cosmetics, and nanotechnology for achieving precise particle size reduction and improving product performance.
During micronization, fats, oils, or waxes are mixed with carbon dioxide, leading to solidification and the formation of a powdered product with altered crystallinity and increased surface area.
Services
- Contract Research Service: Feasibility, optimization, scale-up
- Patent licensing and co-development
- Production
To further expand our impact, we are actively seeking partnerships for collaborative development initiatives.
Join us in exploring co-developing innovative solutions that drive progress in the industry.
Patent Licencing
Patents:
- Extraction of compounds from microalgae (continuous process, no drying step)
- Sterilization with pouches or blisters
- Encapsulation using nanoliposomes or LNPs (process and equipment patent)
Production
Providing a Global Alternative Solution
After conducting successful feasibility and scale-up studies, we offers the following services:
- Scalable Modular Unit Design: we assist in dimensioning scalable modular units tailored to your specific needs.
- Implementation of Units: We support the implementation of units based on the outcomes of our studies.
- Financial Intervention and Co-Financing: we can provide financial support or co-finance projects, offering different legal structures such as dedicated subsidiaries.
- Pilot Testing and Production: Leveraging ScCO2 technology, we specialize in extraction, particle generation, encapsulation of compounds and sterilization processes.
Reduce OPEX & CAPEX
Optimizing Engineering Techniques for Cost-effective Results
Our engineering techniques prioritize minimizing pressure, process volume, flow, and time in CO2 extraction to reduce operational (OPEX) and capital expenditures (CAPEX). However, it is crucial to balance these parameters with product yield and quality. The combination of product quality, yield, and costs determines the economic viability of our extraction process.